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Job Responsibilities/崗位職責(zé)： 1.Be familiar with the application of analytical methods for ADCs, such as DAR, residual free drug, aggregation level, endotoxin, etc. 熟悉ADC質(zhì)量分析的技術(shù)手段，例如DAR、游離藥物、聚集體、內(nèi)毒素檢測等； 2.Responsible for the quality analysis and data interpretation of ADC and linker-payload, including SEC, HIC, RP-HPLC, CE-SDS et al. Knowledge of ADC potency evaluation methods, as ELISA, SPR or Linker-payload characterization methods, nuclear magnetic resonance (NMR), mass spectrometry (MS), inductively coupled plasma mass spectrometry (ICP-MS)，and gas chromatography (GC), et al. are preferred. 負(fù)責(zé)ADC和毒素連接子（linker-payload）的質(zhì)量分析和數(shù)據(jù)解讀，包括：SEC、HIC、RP-HPLC、CE-SDS等。了解ADC的活性評價方法例如：ELISA、SPR 或者Linker-payload的表征手段核磁共振（NMR）、質(zhì)譜（MS）、電感耦合等離子體質(zhì)譜（ICP-MS）、氣相色譜（GC）等分析方法者優(yōu)先； 3.Support quality research and analytical method development, validation, and transfer for ADC small molecule intermediates and ADC during process development, IND application, and early clinical stages. 支持ADC小分子中間體和ADC藥物在工藝開發(fā)、IND申報階段和早期臨床階段的質(zhì)量研究和分析方法開發(fā)、確認(rèn)與轉(zhuǎn)移； 4.ADC analysis related trouble-shooting. 解決出現(xiàn)的ADC分析方法的相關(guān)問題； 5.Maintain laboratory equipment and ensure compliance with safety, environmental, and quality standards. 維護(hù)實(shí)驗(yàn)室設(shè)備，確保實(shí)驗(yàn)操作符合安全、環(huán)境和質(zhì)量標(biāo)準(zhǔn)。